Non-invasive ventilation in acute exacerbation of COPD with mild to moderate type 2 respiratory failure

Original Article

Author Details : Jaykumari Choudhary, Suprova Chakraborty*, Ganesh Patel

Volume : 6, Issue : 3, Year : 2021

Article Page : 143-151

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Background: Chronic obstructive pulmonary disease is a syndrome of progressive airflow limitation caused by abnormal inflammatory reaction of airway and lung parenchyma. Risk factor for development of COPD is a complex interaction of genetic factors and many environmental exposures, with the cigarette smoking being the most common etiological agent.
Materials and Methods: It is a prospective observational comparative study conducted among patient with mild to moderate type 2 respiratory failure, secondary to acute exacerbation of Chronic Obstructive Pulmonary Disease admitted in chest ward department of Respiratory medicine, Late Shri Lakhi Ram Agrawal Memorial Medical College, Raigarh, Chhattisgarh, India for a period of one year from April 2020- April 2021.
Results: A total 60 patients were studied. Out of which, 30 patients in study group for whom noninvasive ventilation support along with conventional treatment was given and remaining 30 patients in comparison group, same treatment was given without non-invasive ventilation support. Both groups had similar demographic, clinical, biochemical profile at the time of admission. Distribution of comorbidities, smoking history were similar as shown below in tables. After application of Non-invasive ventilation along with conventional treatment in study group, the result showed that mean hours of NIV use in study group was 27 hours and mean hours of Oxygen use in comparison group was 98 hours. 
Conclusions: Use of non-invasive ventilation in acute exacerbation of COPD, with mild to moderate type 2 respiratory failure, reduced tachypnoea, tachycardia, after 4 hours. There were improvement in oxygen saturation after 4 hours, improvement in PH also occurred after 4 hours by 0.04. Non-invasive ventilation gives rest to fatigued inspiratory muscle so work of breathing is reduced. It also restores functional and biochemical changes associated with fatigued muscle so all complication were reduced with use of noninvasive ventilation.

Keywords: Non-invasive ventilation, COPD, Type 2 respiratory failure

How to cite : Choudhary J, Chakraborty S, Patel G, Non-invasive ventilation in acute exacerbation of COPD with mild to moderate type 2 respiratory failure. IP Indian J Immunol Respir Med 2021;6(3):143-151

Copyright © 2021 by author(s) and IP Indian J Immunol Respir Med. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 09-06-2021

Accepted : 31-07-2021

Available online : 29-09-2021

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