Polymyxin B infusion related respiratory arrest: A case report

Case Report

Author Details : Suresh Ramasubban, Subhajit Sen*, M. Surya Kumar, Sanjay Bhaumik, Debasis Rout

Volume : 6, Issue : 4, Year : 2021

Article Page : 241-244


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A 73 years old male, known hypertensive on medication, with the history of SARS-CoV-2 infection nine months ago, presented to us with mucormycosis, he was treated with Liposomal amphotericin B initially. He developed acute kidney injury with recurrent pulmonary oedema requiring ICU admission and Haemodialysis. He later developed catheter related blood stream infection that grew Carbapenem resistant Klebsiella pneumonia and was started on Polymyxin B. However from day 3 of antibiotics he started to develop recurrent respiratory arrest with no apparent cause. He required a brief period of mechanical ventilation and was successfully weaned. He had recurrent such episodes with no apparent cause. After extensive work up and literature search it was diagnosed as Polymyxin B induced respiratory failure. Polymyxins were stopped, patient was discharged in a stable condition after five days of further observation and is currently on follow up with no such episode of dyspnoea.

Keywords: Respiratory failure, Polymyxin B, Neuromuscular blockade

How to cite : Ramasubban S, Sen S, Kumar M S, Bhaumik S, Rout D, Polymyxin B infusion related respiratory arrest: A case report. IP Indian J Immunol Respir Med 2021;6(4):241-244

Copyright © 2021 by author(s) and IP Indian J Immunol Respir Med. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)

Article History

Received : 25-10-2021

Accepted : 22-12-2021

Available online : 31-12-2021

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