Get Permission Kumar, Anand, and Bhoi: Mesenchymal stem cell-derived multivesicular bodies: Is it innovative novel cell-based therapeutic adjunct for trauma hemorrhagic shock patients?

Multivesicular bodies (MVBs) is very small (30–1000 nm) membrane-bound vesicles, also called extracellular vesicles (EVs). MVBs are secreted from intracellular matrix through the blending with the plasma membrane. MVBs also released from different cells types under normal and abnormal situations. Interesting, MVBs hold complex of delivery molecules, contain proteins and RNAs, and communicate this message to nearby cells to alter immune system, cell death, formation of blood vessels and inflammation. Previous studies reported that MSC-MVBs act as anti-inflammatory effects in many inflammations associated infection by delivering the complex of cargo molecule (miRNAs and immunomodulatory proteins) to macrophages. MSC-MVBs may promise used as an innovative stem cell free therapeutic to treat HS-induced lung injury. 1, 2, 3 MSC-MVBs can be innovative therapeutic option for the T/HS patients. Need to be attention.

Figure 1

 IL-10 and immune reactivity via B-Cells. 4

https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/bb750b86-cb5e-4238-a931-1948087a7ab1/image/2564b339-71de-4945-9294-6e9995073458-uimage.png

Source of Funding

None.

Conflict of Interest

None.

Acknowledgement

None.

References

1 

M Kumar S Bhoi Impaired hematopoietic progenitor cells in trauma hemorrhagic shockJ Clin Orthop Trauma2016742825

2 

M Kumar S Bhoi S Keshava Human-induced pluripotent stem cells derived hematopoietic failure among trauma hemorrhagic shockJ Clin Orthop Trauma201910226973

3 

M Fioranelli RM Grazia Twenty-five years of studies and trials for the therapeutic application of IL-10 immunomodulating properties. From high doses administration to low dose medicine new paradigmJ Integr Cardiol2014112610.15761/JIC.1000102

4 

Y Zhang X Zhang H Zhang P Song W Pan P Xu Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell PolarizationFront Immunol20221281116410.3389/fimmu.2021.811164

5 

A Zeineddin F Wu JF Dong H Huang L Zou W Chao trauma-derived extracellular vesicles are sufficient to induce endothelial dysfunction and coagulopathyShock20225813844

6 

DR Potter BY Miyazawa SL Gibb X Deng PP Togaratti RH Croze Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and traumaJ Trauma Acute Care Surg201884224556



jats-html.xsl


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

  • Article highlights
  • Article tables
  • Article images

Article History

Received : 28-02-2023

Accepted : 15-04-2023


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/ 10.18231/j.ijirm.2023.009


Article Metrics






Article Access statistics

Viewed: 503

PDF Downloaded: 149